The new liquid mass spectrometer model, the LCMS-8080, is a completely new development with a focus on maximizing analysis sensitivity.
Use:
- development and production of medicines;
- drug screening;
- clinical researches;
- environmental monitoring and analysis of wastewater pollution;
- sanitary control of feed, food products, and food raw materials.
Features:
- quantitative determination of compounds at the level of femtograms in samples with a complex matrix (extracts from food or blood plasma);
- the latest high-temperature ionization source, patented desolvation system HSID (Hot Source Induced Desolvation);
- an original design and heavy-duty impact cell evacuation system ensures efficient ionization sample and minimum ion losses on the way from the ionization system to the detector.
Technical characteristics of the device:
- range of determined masses, m / z - 10 - 1500;
- sensitivity:
- electrospray (ESI);
- registration of positively charged ions (for 1 pg of reserpine S / N> 6000 (RMS));
- MRM transitions;
- resolution: R <0.7;
- minimum time between measurements (pause time), ms - 5;
- minimum measurement time (dwell time), ms - 1;
- scanning speed, amu / sec - up to 5,000;
- time of switching the polarity of ionization, ms - 20;
- ionization method:
- electrospray (ESI) (standard);
- atmospheric pressure chemical ionization (APCI) (optional);
- the range of the mobile phase feed rate - from 5 μl / min to 3 ml / min;
- MRM transition speed, MRM / sec - up to 166;
- maximum HSID temperature, ° C - 300;
- maximum sample temperature ° C - 500;
- analysis modes:
- Q1 Scan/SIM;
- Q3 Scan/SIM;
- MRM;
- Precursor ion scan
- Product ion scan
- Neutral loss scan
Technical characteristics of the mass analyzer and detector:
- mass analyzer - mass filter of the quadrupole type with a prefilter;
- impact cell - ultrafast impact cell with an axial field;
- detector - secondary electron multiplier with conversion dynode;
- detection system - counting impulses;
- ion detection - positive / negative ion detection using UniField technology.
Software:
- workstation - LabSolutions LCMS for LCMS-8080;
- operating system - Windows 7;
- HPLC device control - Prominence and Nexera series;
- LCMS-8080 and interface;
- work in MS Scan mode (up to 200 operations), SIM (up to 200 operations);
- work in MS / MS MRM mode (up to 200 events);
- Precursor ion scan (up to 200 operations);
- product ion scan (up to 200 operations);
- registration of losses of neutral particles (Neutral loss scan) (up to 200 operations);
- auto-tuning - possible to optimize sensitivity and resolution in positive and negative ionization modes, as well as mass calibration.